Dehydroepiandrosterone (DHEA) Supplements and Their Potential Health Benefits for the Elderly

Dehydroepiandrosterone (DHEA) is a hormone involved in various physiological processes in the body. It is produced by the adrenal glands. In the elderly population, levels of DHEA decline, leading to age-related health conditions such as cardiovascular disease, type 2 diabetes, and frailty. DHEA supplements have been investigated as a potential therapeutic option for these and other health conditions in the elderly.

Research has shown that DHEA supplementation may have several potential benefits for the elderly. One study by Morley and Arlt (2019) found that DHEA supplementation may improve bone density, muscle strength, and physical function in older adults. This improvement may reduce the risk of falls and fractures, major concerns in the elderly population. Additionally, a randomized controlled trial by Wu et al. (2019) found that DHEA supplementation improved cognitive function in older adults, particularly in memory and attention.

DHEA supplements may also have potential benefits for cardiovascular health in the elderly population. A meta-analysis by Kim and Cho (2021) found that DHEA supplementation improved cardiovascular risk factors in postmenopausal women, such as total cholesterol, LDL cholesterol, and triglycerides. However, further studies are needed to find out the long-term effects of DHEA supplementation on cardiovascular outcomes.

Despite the potential benefits of DHEA supplements, it is essential to note that high doses of DHEA may have adverse effects, such as increased anxiety and aggression, according to a study by Maninger et al. (2009). Moreover, DHEA supplements may interfere with the body's natural hormone production and regulation, leading to further complications.

Therefore, it is crucial to approach DHEA supplementation cautiously and seek advice from a healthcare provider before starting any supplements. Individuals should not use DHEA supplements to replace prescribed medications or as a sole treatment option for any health condition.

In conclusion, while there is evidence to suggest that DHEA supplements could have potential health benefits for the elderly, it is essential to conduct further research to fully understand its effects on various health conditions and the potential risks associated with its use. Elderly individuals considering DHEA supplementation should consult a healthcare provider and be cautious when using supplements.

References:

Kim, J. E., & Cho, H. C. (2021). The effect of dehydroepiandrosterone on cardiovascular disease risk factors in postmenopausal women: A systematic review and meta-analysis. Maturitas, 143, 1-8.

Maninger, N., Wolkowitz, O. M., Reus, V. I., Epel, E. S., & Mellon, S. H. (2009). Neurobiological and neuropsychiatric effects of dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS). Frontiers in Neuroendocrinology, 30(1), 65-91.

Morley, J. E., & Arlt, W. (2019). Dehydroepiandrosterone supplementation in older adults. The Journal of Clinical Endocrinology & Metabolism, 104(5), 1545-1556.

Wu, J., Ge, X., Zhu, D., & Li, C. (2019). Effects of Dehydroepiandrosterone Supplementation on Cognitive Function and Activities of Daily Living in Older Adults with Mild to Moderate Cognitive Impairment. Journal of the American Geriatrics Society, 67(11), 2267-2272.